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04:30

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[The efficacy of prolonged-action nitrates in stenocardia]

A N Shelest, E I Shapkin, B G Cherevatov

    Vrachebnoe Delo
    |August 1, 1989
    PubMed

    Insights

    Long-acting nitrates, specifically nitrogranulong, effectively treat chronic ischemic heart disease. This drug reduces chest pain and improves physical tolerance in patients with this condition.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Chronic ischemic heart disease poses significant challenges in patient management.
    • Long-acting nitrates are a key therapeutic option for managing ischemic heart conditions.

    Purpose of the Study:

    • To evaluate the therapeutic efficacy of long-acting nitrates.
    • To assess changes in clinical and hemodynamic indices in patients with chronic ischemic heart disease.

    Main Methods:

    • Study involved 91 patients diagnosed with chronic ischemic heart disease.
    • Therapeutic efficacy was assessed using the native drug nitrogranulong.
    • Hemodynamic and clinical indices were monitored.
    • Bicycle ergometry was used to evaluate physical tolerance.

    Main Results:

    • Nitrogranulong demonstrated a significant effect on hemodynamics.
    • Complete disappearance or reduction of stenocardia attacks was observed.
    • Increased tolerance to physical loads was evidenced by ergometric data.

    Conclusions:

    • Long-acting nitrates, exemplified by nitrogranulong, are effective in managing chronic ischemic heart disease.
    • The drug positively impacts hemodynamic parameters and improves patient quality of life.

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