Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Signaling01:30

Bacterial Signaling

29.5K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
29.5K
Hand hygiene01:23

Hand hygiene

5.2K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
5.2K
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

84
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
84
Surface Membrane Barriers01:18

Surface Membrane Barriers

3.0K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
3.0K
Cleaning, Sterilization, and Disinfection01:30

Cleaning, Sterilization, and Disinfection

11.5K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
11.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From paradox to population impact: Rethinking strengthening in knee osteoarthritis - A state-of-the-art review.

Osteoarthritis and cartilage open·2026
Same author

Periprosthetic joint infection as failure of containment: A causal and probabilistic framework.

Journal of orthopaedic translation·2026
Same author

Characteristics and Outcomes of Younger Traditional Medicare Beneficiaries Who Have a Disability and Underwent Elective Inpatient Total Hip Arthroplasty.

The Journal of arthroplasty·2026
Same author

Disparities in Total Knee Arthroplasty Outcomes: A Comparison Between Traditional Medicare Beneficiaries in Puerto Rico and the U.S. Mainland.

Journal of racial and ethnic health disparities·2026
Same author

A novel host-based strategy for detecting low-grade prosthetic joint infection using immune cell pattern in synovial fluid.

Molecular medicine (Cambridge, Mass.)·2026
Same author

The role of neutrophils in the pathophysiology of knee osteoarthritis : a review.

Bone & joint research·2026

Related Experiment Video

Updated: Apr 25, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

4.4K

Antibacterial surface treatment for orthopaedic implants.

Jiri Gallo1, Martin Holinka2, Calin S Moucha3

  • 1Department of Orthopaedics, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital, I. P. Pavlova 6, Olomouc 77520, Czech Republic. jiri.gallo@volny.cz.

International Journal of Molecular Sciences
|August 14, 2014
PubMed
Summary

Preventing implant-associated infections requires tackling biofilm formation and immune suppression. Novel "smart" surfaces are needed to combat bacterial adhesion and infection risks in medical implants.

More Related Videos

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
06:36

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

Published on: March 14, 2025

1.0K
A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess
03:44

A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess

Published on: June 6, 2025

757

Related Experiment Videos

Last Updated: Apr 25, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

4.4K
Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness
06:36

Effects of Mechanical Methods Used in Peri-implantitis Treatment on Implant Surface Decontamination and Roughness

Published on: March 14, 2025

1.0K
A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess
03:44

A Unique Mouse Model for Quantitative Assessment of Biofilm Formation on Surgical Implants in Subcutaneous Abscess

Published on: June 6, 2025

757

Area of Science:

  • Biomaterials Science
  • Infectious Diseases
  • Immunology

Background:

  • Increased use of medical implants leads to a rise in associated infections.
  • Biofilm formation on implants is facilitated by suppressed local immune responses and avascular scar tissue.
  • Bacterial adhesion is a critical step in developing implant-associated infections, particularly periprosthetic joint infections.

Purpose of the Study:

  • To review current knowledge on antimicrobial surface treatments for preventing prosthetic joint infection.
  • To discuss strategies for minimizing bacterial adhesion and inhibiting biofilm formation.
  • To highlight the need for "smart" anti-infective surfaces and translational research.

Main Methods:

  • Review of existing literature on antimicrobial surface treatments for medical implants.
  • Analysis of pathogenic mechanisms in biomaterial-associated infections, including bacterial adhesion and biofilm formation.
  • Discussion of various surface treatment modalities and their potential clinical applications.

Main Results:

  • Several surface treatment modalities have been proposed to combat implant-associated infections.
  • Effective prevention requires targeting both biofilm formation and local immune suppression.
  • A significant gap exists between proposed anti-infective strategies and their clinical implementation.

Conclusions:

  • Future anti-infective surfaces should be "smart," responding to low bacterial loads.
  • Translational science is urgently needed to bridge the gap between research and clinical practice for implant infection prevention.
  • Concurrent strategies targeting bacterial adhesion and immune response are crucial for preventing periprosthetic joint infections.