Nanostructure-based platforms-current prospective in ophthalmic drug delivery

Area of Science:

• Ophthalmology
• Pharmaceutics
• Nanotechnology

Background:

• Topical ocular drug delivery faces challenges due to rapid drug washout.
• Low ocular bioavailability limits the effectiveness of conventional eye drop formulations.
• Existing methods struggle to prolong drug action and minimize pre-corneal drug loss.

Purpose of the Study:

• To review novel nanocarrier systems for enhanced ocular drug delivery.
• To explore the potential of hydrophilic nanogels, solid lipid nanoparticles, and nanosponges.
• To assess the impact of these nanocarriers on drug bioavailability and therapeutic efficacy.

Main Methods:

• Review of recent scientific literature on nanocarrier-based ocular drug delivery.
• Analysis of approaches including hydrophilic nanogels, solid lipid nanoparticles, and nanosponges.
• Evaluation of methods to prolong ocular residence time and minimize drug loss.

Main Results:

• Hydrophilic nanogels, solid lipid nanoparticles, and nanosponges show promise for ocular drug delivery.
• These nanocarriers can significantly prolong ocular residence time.
• They effectively minimize pre-corneal drug loss, leading to improved bioavailability.

Conclusions:

• Novel nanocarrier systems offer a promising solution to enhance ocular drug bioavailability.
• These approaches can improve therapeutic efficacy by ensuring sustained drug release.
• Efficient ocular drug delivery remains a significant challenge, necessitating continued research.