Related Experiment Video
Updated: Apr 25, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
Published on: October 27, 2020
TGF-β1 mediates estrogen receptor-induced epithelial-to-mesenchymal transition in some tumor lines
Dong-Mei Fan1, Peng-Wei Qi, She-Gan Gao
1Department of Gynecology, The 1st Affiliated Hospital of He'nan University of Science and Technology, LuoYang, 471003, People's Republic of China.
Abstract:
More and more studies have reported that epithelial-mesenchymal transition (EMT) involved in the process of cancer development and progression occurs. The EMT also plays an important role in the movement and transfer of the tumors. Transforming growth factor-β (TGF-β) could induce the EMT in some cancer cell types. However, the mechanism underlying this transition process has also not been entirely clarified. In this study, the results indicated that TGF-β1-mediated EMT in the tumor was associated with the estrogen receptor (ER). The decreased expression of vimentin and snail resulted in the decrease of the ER expression by small interfering RNA-mediated silencing and preventing the TGF-β-induced EMT. In conclusion, our results indicated that TGF-β1 is an estrogen receptor signaling and essential novel downstream targets and could act as an important factor in the TGF-β-induced EMT.
Related Concept Videos
TGF - β Signaling Pathway
Mitogens and the Cell Cycle
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Tumor Microenvironment
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...

