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Multiple consecutive cycles of ovulation induction with human menopausal gonadotropins
M P Diamond1, A H DeCherney, P Baretto
1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510.
Summary
Human menopausal gonadotropins (hMG) can be safely administered in multiple successive cycles for ovulation induction. Ovarian response remains consistent, showing no clinical impairment even after 3-12 cycles.
Area of Science:
- Reproductive endocrinology
- Infertility treatments
Background:
- Ovulation induction is a key treatment for infertility.
- Human menopausal gonadotropins (hMG) are commonly used for this purpose.
Purpose of the Study:
- To evaluate the impact of multiple successive cycles of hMG administration on ovarian response.
- To determine if repeated hMG use affects ovulation induction efficacy.
Main Methods:
- Administration of human menopausal gonadotropins (hMG) in 3-12 immediately successive cycles.
- Monitoring ovarian response through peak estradiol (E2) levels.
- Tracking the day of human chorionic gonadotropin (hCG) administration.
Main Results:
- Peak E2 levels remained similar across multiple successive cycles.
- The day of hCG administration did not significantly change.
- Ovarian response was consistent throughout the treatment period.
Conclusions:
- Human menopausal gonadotropins (hMG) can be administered in multiple successive cycles for ovulation induction.
- Clinically significant impairment of ovarian response was not observed with repeated hMG use.
- This supports the continued use of hMG in successive cycles for eligible patients.