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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Physical activity in chronic kidney disease: a plausible approach to vascular calcification?

Carlo Basile1, Carlo Lomonte, Piero Lisi

  • 1Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti (BA), Italy.

Kidney & Blood Pressure Research
|August 14, 2014
PubMed

Insights

Vascular calcification (VC) is common in Chronic Kidney Disease (CKD). Lifestyle changes, particularly physical activity (PA), may offer a cost-effective strategy to manage VC progression in CKD patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Exercise Physiology

Background:

  • Vascular calcification (VC) affects 40-80% of Chronic Kidney Disease (CKD) patients, indicating a significant clinical challenge.
  • The pathogenesis of VC is complex, involving an imbalance between calcification promoters and inhibitors, exacerbated by traditional cardiovascular risk factors.
  • Existing pharmacological strategies for VC have yielded conflicting results, highlighting the need for alternative approaches.

Purpose of the Study:

  • To review the rationale and current evidence supporting lifestyle modification as a strategy for treating vascular calcification (VC) in Chronic Kidney Disease (CKD).
  • To specifically focus on the potential of physical activity (PA) as a cost-effective intervention for attenuating VC deposition and progression.

Main Methods:

  • Systematic review of existing literature on vascular calcification (VC) in Chronic Kidney Disease (CKD).
  • Analysis of studies investigating the role of lifestyle modification, with a specific emphasis on physical activity (PA).
  • Evaluation of the interplay between calcification promoters and inhibitors in the context of CKD and VC.

Main Results:

  • Evidence suggests that a comprehensive risk modification approach, including lifestyle changes, may be more effective than targeting individual risk factors for VC.
  • Physical activity (PA) is identified as a promising, cost-effective strategy to potentially mitigate VC progression in CKD patients.
  • The cumulative and prolonged exposure to multiple risk factors in CKD underscores the importance of holistic management strategies.

Conclusions:

  • Lifestyle modification, particularly physical activity (PA), presents a viable and potentially cost-effective strategy for managing vascular calcification (VC) in Chronic Kidney Disease (CKD).
  • Further research is warranted to establish optimal PA protocols and confirm its efficacy in attenuating VC progression and improving cardiovascular outcomes in CKD.

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