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Increased corneal epithelial permeability after overnight sleep.

Tiana Leung¹, Yixiu Zhou¹, Heather M French¹

¹Clinical Research Center, School of Optometry, University of California, Berkeley, California, United States.

Investigative Ophthalmology & Visual Science

|August 14, 2014

Summary

Human corneal epithelial permeability, a measure of barrier function, increases after sleep. This permeability varies significantly with ethnicity and age, with Asians and older individuals showing higher permeability.

Keywords:

age cornea corneal epithelial permeability diurnal ethnicity fluorometry race sex

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Area of Science:

Ophthalmology
Corneal Physiology
Epithelial Barrier Function

Background:

The corneal epithelium forms a critical barrier.
Understanding factors influencing this barrier is vital for ocular health.
Diurnal variations and demographic factors may affect corneal barrier integrity.

Purpose of the Study:

To investigate the influence of ethnicity, sex, age, and diurnal variation on human corneal epithelial permeability.
To quantify corneal epithelial permeability to sodium fluorescein (Pdc) in relation to time awake.
To identify demographic and temporal factors affecting corneal barrier function.

Main Methods:

Collected Pdc data from 374 noncontact lens wearers at various times post-awakening.
Utilized mixed-effect models to analyze associations between Pdc and time awake, age, sex, and ethnicity.
Evaluated Pdc during the initial recovery period (0-2 hours awake) and the plateau period (>2 hours awake).

Main Results:

Corneal epithelial permeability (Pdc) significantly decreased with increasing time awake in the initial recovery period.
Asians exhibited significantly higher Pdc compared to non-Asians across all time points.
Pdc increased with age, and males showed a trend towards higher Pdc in the early recovery period.

Conclusions:

Corneal epithelial barrier function demonstrates a diurnal pattern, increasing after overnight sleep.
Ethnicity and age are significant determinants of baseline corneal epithelial barrier function.
These findings highlight the importance of considering demographic and temporal factors in corneal physiology research.