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Updated: Apr 25, 2026
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
[Research progress in receptors involved in rotavirus infection]
Abstract:
Rotaviruses, which are recognized as one of the major etiological agents among infants and young children with diarrhea, consist of three concentric layers of protein capsid with the enclosed double-stranded RNA genome. Rotaviruses infect host cells mainly by identifying the specific receptors on cell surfaces and binding to them. Therefore, receptors are important factors for viruses infecting cells. So far, there have been many receptors found to be involved in rotavirus infection, including sialic acid, integrin, Toll-like receptor, and blood group antigen. This article provides an overview of receptors involved in rotavirus infection.
Insights
Rotaviruses cause diarrhea in children by binding to specific cell receptors. This overview details key receptors like sialic acid and integrins involved in rotavirus infection.
Area of Science:
- Virology
- Molecular Biology
Context:
- Rotaviruses are a primary cause of severe diarrhea in infants and young children globally.
- Viral entry into host cells is a critical step in infection, mediated by specific cellular receptors.
Purpose:
- To provide a comprehensive overview of the cellular receptors implicated in rotavirus infection.
- To highlight the diverse range of molecules that facilitate rotavirus cellular entry.
Summary:
- Rotaviruses possess a multi-layered protein capsid enclosing a double-stranded RNA genome.
- Viral attachment and entry are facilitated by interactions with various host cell surface receptors, including sialic acid, integrins, Toll-like receptors, and blood group antigens.
- Understanding these receptor interactions is crucial for comprehending rotavirus pathogenesis.
Impact:
- This review consolidates current knowledge on rotavirus receptors, aiding researchers in developing targeted antiviral strategies.
- Identifying key viral entry factors can inform the development of novel diagnostics and therapeutics for rotavirus infections.
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