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Updated: Apr 25, 2026

Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Spurious platelet count due to cryoglobulins in a patient with smoldering myeloma
Naveen Kakkar1, M Joseph John, Amrith Mathew
1Department of Pathology, Hemato-Oncology and Bone Marrow (Stem cell) Transplant Unit, India.
Use of automated hematology analyzers for routine blood count reporting has increased the reproducibility and accuracy of test results. However, at times, these instruments may generate spurious test results. Such results can result in inappropriate investigations or treatment decisions in patients. Spuriously normal or high platelet counts carry the risk of under diagnosis of the true thrombocytopenia with adverse clinical implications. We present a patient with smoldering myeloma with spurious platelet count due to cryoglobulins.
Use of automated hematology analyzers for routine blood count reporting has increased the reproducibility and accuracy of test results. However, at times, these instruments may generate spurious test results. Such results can result in inappropriate investigations or treatment decisions in patients. Spuriously normal or high platelet counts carry the risk of under diagnosis of the true thrombocytopenia with adverse clinical implications. We present a patient with smoldering myeloma with spurious platelet count due to cryoglobulins.

