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Published on: March 30, 2018
Hodgkin's lymphoma mimicking tuberculosis in cervical lymph nodes
Anna Szumera-Ciećkiewic1, Monika Prochorec-Sobieszek, Ewa Lech-Marańda
1Anna Szumera-Ciećkiewicz Department of Diagnostic Hematology Institute of Hematology and Transfusion Medicine I. Gandhi 14 02-776 Warsaw, Poland tel. +48 22 349 62 96 fax +48 22 349 64 94
Abstract:
The authors present a case description of an 81-year-old male with general symptoms (fever, night sweats, weight loss) and cervical/supraclavicular lymphadenopathy. The revised lymph node histopathological examination revealed nodular sclerosis classical Hodgkin's lymphoma associated with abundant tuberculosis-mimicking granulomatous reaction. The diagnosis may be difficult due to similarities in clinical course, laboratory tests and imaging. The morphology of Hodgkin-Reed-Sternberg cells and the immunohistochemical profile are the most helpful in differential diagnosis. In cases where granulomas coexist with negative acid-fast staining, pathologists should always recommend evaluation of further and broader diagnostic procedures to exclude Mycobacterium tuberculosis infection.
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