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Plasma B-type natriuretic peptide is a useful tool for assessing coronary heart disease risk in a Japanese general

Takuya Hasegawa1, Masanori Asakura1, Kazuo Eguchi2

  • 1Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|August 15, 2014
PubMed

Insights

Plasma B-type natriuretic peptide (BNP) levels indicate higher coronary heart disease (CHD) risk in community populations. Elevated BNP effectively identifies individuals with moderate to high CHD risk, even without existing heart or kidney issues.

Area of Science:

  • Cardiology
  • Biomarkers
  • Preventive Medicine

Background:

  • B-type natriuretic peptide (BNP) is linked to cardiovascular prognosis.
  • Accumulated cardiovascular risk factors predict future disease.
  • BNP's role as a comprehensive marker for risk factor accumulation is under-explored.

Purpose of the Study:

  • To investigate if plasma BNP levels serve as a comprehensive marker for accumulated cardiovascular risk factors.
  • To assess the association between BNP levels and coronary heart disease (CHD) risk in a community-dwelling population.

Main Methods:

  • A study of 1530 community-dwelling Japanese subjects (mean age 62) without heart disease or renal dysfunction.
  • Coronary heart disease (CHD) risk was estimated using the Framingham function, categorizing participants into low, moderate, and high-risk groups.
  • Plasma BNP levels were measured and analyzed for their ability to detect moderate- and high-risk subjects.

Main Results:

  • The prevalence of moderate- and high-risk CHD subjects increased with higher plasma BNP levels in both genders.
  • Plasma BNP demonstrated modest ability to detect these risk groups (AUC 0.755 for men, 0.700 for women).
  • Optimal BNP thresholds for identifying moderate- and high-risk individuals were 12.0 pg/mL and 22.0 pg/mL, respectively, with good sensitivity and specificity.

Conclusions:

  • Elevated plasma BNP levels are associated with increased CHD risk in a population free from overt heart disease or renal dysfunction.
  • BNP can serve as a valuable biomarker for identifying individuals with accumulated cardiovascular risk factors.
  • These findings support the use of BNP testing in community health checkups for cardiovascular risk assessment.

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