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[Vitamins A and E in digestive cancers].

M Barthet1, M Rotily, P Berthezene

  • 1Unité n. 315, I.N.S.E.R.M., Marseille.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|January 1, 1989
PubMed
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Digestive cancer patients showed lower vitamin A, retinol binding protein (RBP), and transthyretin (TT) levels. These vitamin changes appear to be a consequence of nutritional alterations caused by the disease, not a direct risk factor.

Area of Science:

  • Biochemistry
  • Oncology
  • Nutritional Science

Background:

  • Digestive cancers are associated with various clinical and biochemical changes.
  • Nutritional status significantly impacts patient outcomes and disease progression.

Purpose of the Study:

  • To investigate plasma levels of vitamins A and E, transthyretin (TT), and retinol binding protein (RBP) in patients with newly diagnosed digestive cancer.
  • To determine the relationship between these biomarkers and the relative risk of digestive cancer.

Main Methods:

  • Assay of plasma vitamin A, vitamin E, TT, and RBP levels in 70 digestive cancer patients and 116 controls.
  • Statistical adjustment for age and sex.
  • Multiple logistic conditional regression analysis to assess the relationship with cancer risk.

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Main Results:

  • Lowered plasma levels of vitamin A, RBP, and TT were observed in digestive cancer patients compared to controls, after adjusting for age and sex.
  • Vitamin E levels were significantly lowered only in patients with esophagus cancer.
  • Transthyretin (TT) level was the sole significant parameter correlating with digestive cancer risk.

Conclusions:

  • The decreased blood levels of vitamin A and its carriers (RBP, TT) in digestive cancer are likely a consequence of disease-induced nutritional alterations.
  • Transthyretin (TT) levels, influenced by nutritional status, may serve as an indicator of these alterations in digestive cancer.