Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Engineered PD1-NKG2D Dual-CAR NK92 cells broaden antitumor target recognition in preclinical tumor models.

Journal of translational medicine·2026

Same author

Molecular Insights into the Extraction and Stripping Mechanisms of UO<sub>2</sub><sup>2+</sup> and Th<sup>4+</sup> by the Externally α-Irradiated Tri-<i>iso</i>-amyl Phosphate.

Inorganic chemistry·2026

Same author

High speed slow-light Michelson interferometer modulators with dual-inductor peaking enhancement.

Optics express·2026

Same author

Optoelectronic co-simulation model for a 3D integrated structure with TSVs based on a micro-ring modulator and driver.

Applied optics·2026

Same author

High-throughput screening to engineer optimal T cell therapies: current knowledge and future prospects.

Frontiers in oncology·2026

Same author

Advances in research on thermogenic substances.

Journal of physiological anthropology·2026

Search research articles

Related Experiment Video

Updated: Apr 25, 2026

Extraction and Analysis of Taiwanese Green Propolis

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

Brazilian green propolis improves immune function in aged mice.

Weina Gao¹, Jianquan Wu¹, Jingyu Wei¹

¹Institute of Health and Environmental Medicine, Tianjin, 300050, China.

Journal of Clinical Biochemistry and Nutrition

|August 15, 2014

Summary

Brazilian green propolis supplementation enhanced immune function in aged mice. It boosted macrophage phagocytosis, T lymphocyte proliferation, and antibody production, indicating a positive effect on innate and adaptive immunity.

Keywords:

aged mice immune function propolis

More Related Videos

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

Related Experiment Videos

Last Updated: Apr 25, 2026

Extraction and Analysis of Taiwanese Green Propolis

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

Area of Science:

Immunology
Gerontology
Natural Products Research

Background:

Aging is associated with a decline in both innate and adaptive immune functions.
Propolis, a natural resin, has shown potential in stimulating immune responses in younger subjects.
Limited research exists on the immunomodulatory effects of propolis in aged populations.

Purpose of the Study:

To investigate the impact of Brazilian green propolis on the immune system of aged mice.
To evaluate dose-dependent effects of propolis on various immunological parameters.

Main Methods:

Eighty aged Kunming mice were divided into control and three experimental groups receiving different doses of Brazilian green propolis (83.3, 157.4, 352.9 mg/kg.bw) for 4 weeks.
Analysis included total polyphenol, flavonoid, cinnamic acid, and artepillin-C content of propolis.
Measured parameters: splenic NK cell cytotoxicity, T lymphocyte proliferation, antibody-producing cells, peritoneal macrophage phagocytosis, ear swelling response, and serum levels of IgG, IgM, hemolysin, and cytokines.

Main Results:

Propolis treatment enhanced peritoneal macrophage phagocytosis at higher doses (157.4 and 352.9 mg/kg.bw).
Ear swelling response, an indicator of cellular immunity, increased across all propolis-treated groups.
Specific antibody production and IgG levels were significantly elevated in mice receiving propolis, particularly at doses of 157.4 and 352.9 mg/kg.bw.

Conclusions:

Brazilian green propolis demonstrates a beneficial effect on both innate and adaptive immune responses in aged mice.
Propolis may serve as a potential natural supplement to support immune health in aging individuals.