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Related Experiment Video

Updated: Apr 25, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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Tempol intake improves inflammatory status in aged mice.

Mayumi Yamato1, Ayumi Ishimatsu2, Yuuki Yamanaka2

  • 1Innovation Center for Medical Redox Navigation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Journal of Clinical Biochemistry and Nutrition
|August 15, 2014
PubMed
Summary

The antioxidant tempol extended lifespan in mice by reducing mortality. This antioxidant treatment also helped normalize body temperature and reduce inflammation, suggesting improved immune function during aging.

Keywords:
agingantioxidantimmunityinflammationoxidative stress

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Area of Science:

  • Gerontology
  • Immunology
  • Oxidative Stress Research

Background:

  • Oxidative stress and chronic low-grade inflammation are hallmarks of aging and age-related diseases.
  • Immune system dysfunction is closely linked to the aging process.

Purpose of the Study:

  • To investigate the effects of long-term antioxidant treatment with tempol on lifespan and age-related physiological changes in mice.
  • To determine if tempol can ameliorate inflammation and improve immune function in aged mice.

Main Methods:

  • Long-term administration of the antioxidant tempol in drinking water to mice.
  • Assessment of lifespan, mortality rates, body weight, visceral adipose tissue, and plasma biochemical parameters.
  • Measurement of body temperature, thiobarbituric acid-reactive substances (TBARS), C-reactive protein (CRP), and ascorbic acid levels.
  • Analysis of lymphocyte populations, specifically CD4 T cells.

Main Results:

  • Tempol treatment significantly extended the lifespan of mice, reducing mortality at 20 months.
  • Tempol partially restored reduced body temperature in aged mice and normalized elevated plasma TBARS and CRP levels.
  • Plasma ascorbic acid levels were increased in tempol-treated mice, and the proportion of CD4 lymphocytes was partially increased.

Conclusions:

  • Long-term administration of the antioxidant tempol extends lifespan in mice.
  • Tempol's life-extending effects are likely mediated by the amelioration of chronic inflammation and enhancement of immune system function through its antioxidant properties.