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Metastasis-associated colon cancer-1 is a novel prognostic marker for cervical cancer
Lan Guo1, Wanggui Lu1, Xuan Zhang1
1Department of Gynaecology and Obstetrics, The First People's Hospital of Chenzhou City Chenzhou, HN 423000, China.
Aims:
To investigate metastasis associated in colon cancer 1 (MACC1) expression in cervical cancer.
Methods:
One hundred and four paraffin-embedded cervical cancer specimens were immunohistochemically analyzed for MACC1 expression. The expression of MACC1 in 8 pairs of cervical cancer and adjacent normal cervical tissues were detected by Real-time PCR.
Results:
MACC1 expression was upregulated in cervical cancer tissues compared with adjacent normal cervical tissues. Patients with higher MACC1 expression had shorter overall survival time, whereas those with lower ASAP1 expression survived longer (P = 0.029). Moreover, high expression of MACC1 was correlated with FIGO stage (P = 0.039) and lymph nodes metastasis (P = 0.003) of this disease. Multivariate analysis revealed that MACC1 was an independent prognostic factor (P = 0.043) for the overall survival of cervical cancer patients.
Conclusion:
Our study suggests that MACC1 may contribute to tumor development and progression in cervical cancer, and that MACC1 could be a useful marker for the prognosis of cervical cancer.
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