[Experimental study on the transplantation of demineralized bone and bone morphogenetic protein (BMP)]

Solid and powdered grafts of demineralized allogenic or xenogenic bone were implanted in rats and rabbits cranial defects and abdomen muscle. Demineralized bone powder (DBP) and bone morphogenetic protein (BMP) healed the defects, as judged by histology, 45Ca incorporation and culture of bone blastocyte (3H-TdR uptake) studies. Histologic evaluation demonstrated predictable osteoinduction by DBP, solid bone and BMP. It shows that BMP might also be a stimulation on the mesenchymal cells to induce their transformation into bone forming cells.