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Recent advances in oesophageal diseases.

David Al Dulaimi1

  • 1Department of Gastroenterology, Alexandra Hospital, Redditch, UK.

Gastroenterology and Hepatology From Bed to Bench
|August 15, 2014
PubMed
Summary

Barrett's esophagus (BE) in China is characterized by a younger average patient age and a lower incidence of esophageal cancer compared to Western countries. Short-segment BE is most common, and risk factors like obesity and GERD are similar across regions.

Area of Science:

  • Gastroenterology and Hepatology
  • Epidemiology
  • Oncology

Background:

  • Barrett's esophagus (BE) is a pre-cancerous condition with poorly characterized disease patterns in China compared to Western countries.
  • Understanding regional variations in BE epidemiology and characteristics is crucial for targeted prevention and management strategies.
  • Esophageal cancer (EC) incidence varies globally, with Iran showing rates exceeding the global average, necessitating studies on influencing factors.

Purpose of the Study:

  • To investigate the epidemiology and characteristics of Barrett's esophagus (BE) in China and compare them with Western countries.
  • To explore the incidence of esophageal cancer in BE patients in China.
  • To examine gender and social disparities in esophageal cancer incidence in Iran and identify risk factors for gastroesophageal reflux disease (GERD).

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Main Methods:

  • Meta-analysis of 69 clinical studies (3873 BE cases) in China (2000-2011) to determine BE prevalence, patient demographics, and cancer incidence.
  • Review article comparing BE disease patterns in Asian and Western countries, analyzing diagnostic criteria variability and risk factors.
  • Ecological study using Iranian cancer registry data (2003-2009) to assess gender and social class influence on EC incidence.
  • Cross-sectional analysis of 50,045 individuals in Iran to identify determinants of GERD, including lifestyle factors like hookah and opium use.

Main Results:

  • BE in China has a lower endoscopic detection rate (1.0%) and younger average patient age (49.07 years) than Western countries, with a male predominance (1.78:1).
  • Short-segment BE is predominant (80.3%), and the incidence of esophageal cancer in BE patients is 1.418 per 1000 person-years, lower than in the West.
  • Esophageal cancer incidence in Iran is highest in northern provinces, with increasing trends in both genders; social class is inversely associated with EC incidence.
  • GERD symptoms are prevalent in Iran, negatively associated with male gender, education, wealth, and nass chewing, but positively associated with BMI, physical activity, smoking, alcohol, and opium use.

Conclusions:

  • BE in China exhibits distinct epidemiological features compared to Western countries, including younger age of onset and a higher proportion of short-segment disease.
  • The lower incidence of esophageal cancer in Chinese BE patients warrants further investigation into potential protective factors, possibly including Helicobacter pylori infection.
  • Standardization of diagnostic criteria for BE is essential for accurate comparisons of disease trends between Asia and the West.
  • Understanding regional risk factors for GERD and EC is vital for developing effective public health interventions, particularly in low- to medium-income countries.