Multiple abdominal veins thrombosis secondary to protein s deficiency - a case report

Area of Science:

• Vascular Medicine
• Hematology
• Internal Medicine

Background:

• Abdominal venous thrombosis commonly manifests as Budd-Chiari syndrome or extrahepatic portal venous obstruction.
• Mixed involvement of multiple abdominal veins is infrequent.
• Simultaneous thrombosis of hepatic vein, inferior vena cava (IVC), portal vein, and renal vein is exceptionally rare.

Observation:

• A unique case presented with concurrent thrombosis of the IVC, hepatic vein, portal vein, and renal vein.
• The patient exhibited deficiencies in protein S and protein C, suggesting a genetic predisposition to thrombosis.
• This complex thrombotic event required comprehensive management.

Findings:

• The patient was successfully managed with anticoagulant therapy.
• This approach proved effective in addressing the extensive venous obstructions.
• The case underscores the importance of identifying underlying coagulation disorders.

Implications:

• This case highlights the possibility of extensive abdominal venous thrombosis beyond typical presentations.
• It emphasizes the critical role of anticoagulant therapy in managing such rare and severe conditions.
• Identifying and managing inherited thrombophilias like protein S and protein C deficiency is crucial for preventing recurrence.