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Hepatic chemerin and chemokine-like receptor 1 expression in patients with chronic hepatitis C

Michał Kukla1, Brygida Adamek2, Marek Waluga1

  • 1Department of Gastroenterology and Hepatology, Medical University of Silesia, Ulica Medyków 14, 40-752 Katowice, Poland.

Biomed Research International
|August 15, 2014
PubMed

Insights

This study found chemerin and its receptor CMKLR1 are expressed in the liver of chronic hepatitis C patients. Serum chemerin levels negatively correlated with hepatic chemerin expression.

Area of Science:

  • Hepatology
  • Immunology
  • Molecular Biology

Background:

  • Chemerin is implicated in chronic hepatitis C (CHC) pathogenesis.
  • Hepatic expression of chemerin and its receptor, chemokine receptor-like 1 (CMKLR1), in CHC remains uninvestigated.

Purpose of the Study:

  • To assess hepatic expression of chemerin and CMKLR1 in CHC patients.
  • To measure serum chemerin concentrations in CHC patients.
  • To correlate these with metabolic and histopathological factors.

Main Methods:

  • Quantitative real-time PCR for hepatic chemerin and CMKLR1 mRNA transcription.
  • Enzyme-linked immunosorbent assay for serum chemerin.
  • Study included 63 nonobese CHC patients.

Main Results:

  • Chemerin and CMKLR1 expression was detected in the livers of all CHC patients.
  • Hepatic expression did not correlate with necroinflammation, steatosis, fibrosis, or metabolic abnormalities.
  • A negative association was observed between serum chemerin and hepatic chemerin expression (r = -0.41, P = 0.006).

Conclusions:

  • This study provides the first evidence of significant chemerin and CMKLR1 expression in the CHC liver.
  • The primary source of hepatic chemerin and CMKLR1 mRNA (hepatocytes vs. other cells) requires further investigation.
Abstract

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