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Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol.

Heidrun Wabnitz1, Dieter Richard Taubert1, Mikhail Mazurenka1

  • 1Physikalisch-Technische Bundesanstalt (PTB), Abbestraße 2-12, 10587 Berlin, Germany.

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Summary

New protocols assess time-domain optical brain imaging instruments. Responsivity and instrument response function (IRF) were measured, aiding in the design and quality assurance of advanced brain imaging technologies.

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Area of Science:

  • Biomedical Optics
  • Medical Instrumentation
  • Neuroimaging

Background:

  • Instrument performance validation is crucial for clinical applications.
  • Time-domain optical brain imaging requires robust quality assurance protocols.
  • The European project nEUROPt aims to optimize optical brain imaging instruments.

Purpose of the Study:

  • To introduce and apply two new protocols for designing and optimizing time-domain optical brain imaging instruments.
  • To present the "Basic Instrumental Performance" protocol for direct measurement of key instrument characteristics.
  • To detail two specific tests: responsivity and instrument response function (IRF).

Main Methods:

  • Developed dedicated solid slab phantoms with known spectral characteristics for responsivity testing.
  • Quantitatively measured the responsivity of four time-domain optical brain imagers.
  • Measured the temporal instrument response function (IRF) for various instruments and combined with simulations.

Main Results:

  • The responsivity of the tested time-domain optical brain imagers was found to be approximately 0.1 m² sr.
  • Simulations demonstrated the relevance of responsivity in diffuse reflectance measurements.
  • The impact of IRF width and shape on contrast for deep brain activation was illustrated through combined measurements and simulations.

Conclusions:

  • The developed protocols facilitate the design and optimization of time-domain optical brain imaging instruments.
  • Responsivity and IRF are critical parameters for assessing instrument performance in optical brain imaging.
  • These methods contribute to the validation and quality assurance of clinical neuroimaging devices.