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Related Experiment Videos

Imaging positron emitting radionuclides generated during radiation therapy.

L G Strauss1, J H Clorius, B Kimmig

  • 1German Cancer Research Centre, Heidelberg.

European Journal of Radiology
|November 1, 1989
PubMed
Summary

Positron emission tomography (PET) can monitor radiation-induced Carbon-11 and Nitrogen-13 radioactivity in patients after radiation therapy. This technique allows for evaluation of activity distribution within the irradiated volume.

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[Not Available].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016

Area of Science:

  • Nuclear Medicine
  • Radiotherapy Physics
  • Medical Imaging

Background:

  • Positron emitting radioisotopes like Carbon-11 (C-11) and Nitrogen-13 (N-13) are generated in vivo during radiation therapy with accelerators >10 MeV.
  • Previous studies have noted the presence of these isotopes, but their utility for monitoring treatment has not been fully explored.

Purpose of the Study:

  • To investigate the feasibility of using state-of-the-art Positron Emission Tomography (PET) technology to monitor the three-dimensional distribution of in vivo generated radioactivity following radiation therapy.
  • To assess if PET can delineate radiation fields by visualizing radiation-induced activity.

Main Methods:

  • Six patients undergoing radiation therapy for colorectal malignancy or bile duct carcinoma were scanned using PET 15-25 minutes post-treatment with a 42 MeV accelerator.

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  • Analysis focused on the concentration and spatial distribution of C-11 and N-13 activity within the irradiated volumes.

    • Main Results:

    • Sufficient concentrations of C-11 and N-13 activity were detected in the irradiated volumes of all six patients.
    • Significant radioactivity was observed at the body surface, enabling radiation field delineation.
    • PET imaging successfully visualized the three-dimensional activity distribution.

    Conclusions:

    • In vivo generated radioactivity, specifically C-11 and N-13, can be effectively monitored using current PET technology after radiation therapy.
    • PET imaging provides a viable method for evaluating radiation-induced activity and delineating treatment fields in real-time.