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Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
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Directional locking in deterministic lateral-displacement microfluidic separation systems.

Sumedh R Risbud1, German Drazer2

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|August 15, 2014
PubMed
Summary
This summary is machine-generated.

We reveal how suspended particles navigate obstacle arrays, finding their motion mimics a point particle with an effective radius. This clarifies directional locking and aids microfluidic separation design.

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Area of Science:

  • Fluid dynamics
  • Particle transport
  • Microfluidics

Background:

  • Analyzing particle trajectories in confined geometries is crucial for microfluidic applications.
  • Understanding particle-obstacle interactions governs separation and capture efficiencies.

Purpose of the Study:

  • To model the trajectory of suspended spherical particles in a square array of obstacles at zero Reynolds number.
  • To establish an equivalent system for particle motion using an effective radius.
  • To analyze directional locking and the "devil's staircase" phenomenon in particle migration.

Main Methods:

  • Dilute approximation for widely separated obstacles.
  • Hydrodynamic and nonhydrodynamic interaction modeling.
  • Derivation of an inequality for migration angle as a function of forcing direction.

Main Results:

  • Particle motion is equivalent to a point particle with an effective radius accounting for interactions.
  • Demonstrated directional locking in particle trajectories.
  • Derived an inequality accurately describing the "devil's staircase" structure.

Conclusions:

  • The effective radius model simplifies analysis of particle behavior in obstacle arrays.
  • Results inform optimal resolution for deterministic lateral-displacement microfluidic systems.
  • Provides insights into collision frequencies for immunocapture devices.