Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A simple method to quantitate circulating immune complexes in different diseases.

N Jayapal, N Shanmugasundaram, P A Thomas

    Indian Journal of Pathology & Microbiology
    |January 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Data-driven predictive maintenance of induction motors using self-supervised and federated learning on noisy current and vibration signals.

    Scientific reports·2026
    Same author

    [Surgical emphysema reduction: A viable alternative in the era of endobronchial valves].

    Revue des maladies respiratoires·2025
    Same author

    Controlled donation after circulatory death lung transplantation: Results of the French protocol including in situ abdominal normothermic regional perfusion and ex vivo lung perfusion.

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2023
    Same author

    In vitro evaluation of growth reticence and anticancer potential of 5α,8α-epidioxy-24ᶓ-methylcholesta-6,22-dien-3β-ol and ergosta-5,7,22-trien-3β-ol bioactive isolated from an edible mushroom Lentinus tuberregium (fr.).

    Environmental research·2022
    Same author

    The evolutionary heritage and ecological uniqueness of Scots pine in the Caucasus ecoregion is at risk of climate changes.

    Scientific reports·2021
    Same author

    Scholarship in Teaching: An Approach to Enhancing the Value and Academic Standing of Teaching.

    Medical science educator·2021

    Quantifying immune complexes (CICs) aids disease diagnosis and prognosis. Elevated CIC levels were found in leprosy, bacterial endocarditis, and systemic lupus erythematosus (SLE), confirming their pathogenic role.

    Area of Science:

    • Immunology
    • Pathogenesis
    • Clinical Diagnostics

    Background:

    • Immune complexes (ICs) play a role in the pathogenesis of diverse diseases, including autoimmune disorders and infections.
    • Quantifying ICs can aid in disease diagnosis and prognosis assessment.

    Purpose of the Study:

    • To evaluate the utility of quantifying circulating immune complexes (CICs) for diagnosis and prognosis.
    • To assess CIC levels in specific diseases like leprosy, syphilis, bacterial endocarditis, and systemic lupus erythematosus (SLE).

    Main Methods:

    • Precipitation of immune complexes using polyethylene glycol.
    • Quantitation of precipitated immune complexes via single radial immunodiffusion.

    Main Results:

    Related Experiment Videos

  • Significantly elevated CIC levels were detected in patients with erythema nodosum leprosum.
  • Higher CIC concentrations were observed in culture-positive bacterial endocarditis.
  • Elevated CICs were also found in patients with systemic lupus erythematosus (SLE).

    • Conclusions:

    • The polyethylene glycol precipitation and single radial immunodiffusion method is effective for quantifying CICs.
    • Elevated CIC levels correlate with disease pathogenesis in conditions like erythema nodosum leprosum, bacterial endocarditis, and SLE.
    • CIC quantitation offers valuable diagnostic and prognostic information for various diseases.