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Genetic polymorphisms in preoperative myocardial infarction

Sefa Senol1, Mehmet Ugur Es2, Gökhan Gokmen3

  • 1Department of Cardiovascular Surgery, Educational and Research Hospital, Elazig, Turkey ssenol2012@gmail.com.

Asian Cardiovascular & Thoracic Annals
|August 15, 2014
PubMed

Insights

Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene polymorphisms were not associated with myocardial infarction with ST-segment elevation in patients undergoing coronary artery bypass grafting. These genetic factors did not prove to be risk factors in the studied population.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Thrombosis Research

Background:

  • Myocardial infarction with ST-segment elevation (STEMI) is a critical cardiovascular event.
  • Coronary artery bypass grafting (CABG) is a common revascularization strategy for STEMI.
  • Genetic predispositions are increasingly investigated for cardiovascular disease risk.

Purpose of the Study:

  • To investigate the association of plasminogen activator inhibitor 1 (PAI-1) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms with STEMI.
  • To compare PAI-1 and MTHFR C677T and A1298C allele frequencies in STEMI patients before CABG versus controls with prior CABG.

Main Methods:

  • Real-time polymerase chain reaction (PCR) was used to determine genetic polymorphisms.
  • A study group comprised 70 STEMI patients scheduled for CABG.
  • A control group consisted of 70 patients with a history of CABG.

Main Results:

  • No significant differences were observed in PAI-1 polymorphisms between the groups.
  • MTHFR C677T and A1298C polymorphisms showed no significant differences between STEMI patients and controls.
  • Allele frequencies for both PAI-1 and MTHFR polymorphisms were comparable between the two groups.

Conclusions:

  • PAI-1 and MTHFR gene polymorphisms are not associated with STEMI in patients undergoing CABG.
  • These specific genetic variations do not appear to be risk factors for STEMI in this patient cohort.
  • Further research may explore other genetic markers in relation to STEMI and CABG outcomes.
Abstract

Keywords:
Coronary artery diseaseMethylenetetrahydrofolate reductase (MTHFR)Myocardial infarctionPlasminogen activator inhibitor 1Polymorphismsingle nucleotide

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