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Updated: Apr 25, 2026

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
HIV vaccine trial exploits a dual and central role for innate immunity
Deborah Heydenburg Fuller1, Laura E Richert-Spuhler2, Nichole R Klatt3
1Department of Microbiology, University of Washington, Seattle, Washington, USA Washington National Primate Research Center, Seattle, Washington, USA fullerdh@u.washington.edu klattnr@u.washington.edu.
Abstract:
Limited understanding of correlates of protection from HIV transmission hinders development of an efficacious vaccine. D. J. M. Lewis and colleagues (J. Virol. 88:11648-11657, 2014, doi:10.1128/JVI.01621-14) now report that vaginal immunization with an HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [C-C motif] receptor 5) and increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity-they may prove to be critical for preventing HIV transmission.
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