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Updated: Apr 25, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
[Comorbidity in 207 cannabis users in a specific outpatient setting]
E Guillem1, S Arbabzadeh-Bouchez2, F Vorspan3
1Service de psychiatrie d'adultes, groupe hospitalier Saint-Louis, Lariboisière, Fernand-Widal (AP-HP), 2, rue Ambroise-Paré, 75010 Paris, France; Consultation cannabis ECIMUD, hôpital Lariboisière, 2, rue Ambroise-Paré, 75010 Paris, France; Inserm U1144, université Paris Descartes, UMR-S 1144, 75006 Paris, France; Université Paris Diderot, UMR-S 1144, 75013 Paris, France.
Cannabis users seeking healthcare frequently experience mood and anxiety disorders, with women showing higher rates of major depressive disorder and eating disorders. This highlights the need for comprehensive psychiatric evaluations in this population.
Area of Science:
- Psychiatry
- Addiction Medicine
- Cannabis Use Disorder
Context:
- Healthcare seeking for problematic cannabis use is increasing in France.
- The study was conducted at Lariboisière hospital, focusing on a specific patient population.
- Data was collected from 207 cannabis users between January 2004 and December 2009.
Purpose:
- To assess addictive and psychiatric comorbidities in cannabis users.
- To identify the prevalence of mood, anxiety, eating, and psychotic disorders.
- To analyze factors associated with gender and healthcare seeking behavior.
Summary:
- High rates of cannabis abuse/dependence were observed (cannabis: 82.1% lifetime), alongside significant comorbidities.
- Mood disorders (MDD: 57.1% lifetime) and anxiety disorders (53.2% current) were highly prevalent, particularly in women.
- Women showed higher rates of major depressive disorder, agoraphobia, PTSD, and bulimia compared to men.
Impact:
- Confirms high comorbidity of mood and anxiety disorders in cannabis-dependent individuals.
- Underscores the necessity of thorough psychiatric evaluations for cannabis users.
- Provides insights into gender-specific differences in psychiatric comorbidities associated with cannabis use.
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