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ID'ing innate and innate-like lymphoid cells
Mihalis Verykokakis1, Erin C Zook, Barbara L Kee
1Committee on Immunology and Department of Pathology, The University of Chicago, Chicago, IL, USA.
Immunological Reviews
|August 16, 2014
Summary
Innate immune cells, including innate lymphoid cells (ILCs), share developmental pathways with adaptive counterparts. This review explores how ID proteins regulate the development of these crucial immune cells.
Area of Science:
- Immunology
- Cell Biology
- Developmental Biology
Background:
- The immune system comprises innate and adaptive branches with distinct cellular activation dynamics.
- Innate immune cells are the primary responders to pathogens.
- Innate lymphoid cells (ILCs) exhibit effector functions mirroring adaptive lymphocytes but can contribute to autoimmune diseases.
Purpose of the Study:
- To review the transcriptional mechanisms governing innate lymphocyte development.
- To highlight the role of ID proteins in innate and innate-like lymphocyte development.
Main Methods:
- Literature review focusing on transcriptional regulation.
- Analysis of the role of ID proteins and E protein transcription factors.
Main Results:
- Innate and adaptive immune cells differ in ID protein expression (constitutive vs. inducible).
- ID proteins antagonize E protein transcription factors crucial for lymphoid development.
- Recent advances reveal reiterative developmental programs in ILCs (ILC1, ILC2, ILC3).
Conclusions:
- Understanding transcriptional control, particularly ID protein function, is vital for innate lymphocyte development.
- ID proteins are key regulators in the development of natural killer cells, ILCs, and natural killer T cells.
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