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Angioedema related to Angiotensin inhibitors

Stephanie E Knecht1, Steven P Dunn2, Tracy E Macaulay3

  • 1Lexington VA Medical Center, Lexington, KY, USA.

Journal of Pharmacy Practice
|August 16, 2014
PubMed

Insights

Angiotensin inhibitors like ACEIs and ARBs offer cardiovascular and renal benefits but can cause rare angioedema. This review guides clinicians on their use, especially in patients with a history of angioedema.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Angiotensin inhibitors, including ACEIs and ARBs, are vital in managing cardiovascular diseases, hypertension, and chronic kidney disease.
  • These drugs significantly reduce morbidity and mortality in conditions like myocardial infarction, stroke, and heart failure.
  • Angioedema is a rare but recognized adverse effect associated with both ACEIs and ARBs.

Purpose of the Study:

  • To review the incidence and cross-reactivity of angioedema associated with ACE inhibitors and ARBs.
  • To provide clinical guidance for prescribing these medications, particularly in patients with a history of angioedema.

Main Methods:

  • Literature review of clinical trials and studies on angioedema incidence and cross-reactivity with ACEIs and ARBs.

Main Results:

  • ACEIs and ARBs are effective in cardiovascular and renal protection.
  • Angioedema is a rare adverse event, but cross-reactivity between ACEIs and ARBs exists.
  • Understanding these risks is crucial for safe clinical practice.

Conclusions:

  • Clinicians must weigh the benefits of ACEIs and ARBs against the risk of angioedema.
  • Careful consideration and patient history are essential when prescribing these agents, especially for patients with prior angioedema.
  • Further guidance is provided for informed clinical decision-making regarding angioedema risk.

Keywords:
angioedemaangiotensin converting enzyme inhibitors (ACEI)angiotensin receptor blockers (ARBs)bradykininrenin-angiotensin-aldosterone system (RAAS) blockade

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