Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and validation of a multimodal risk prediction model for early COPD progression: a retrospective study integrating clinical, functional, and CT radiomic features.

Therapeutic advances in respiratory disease·2026
Same author

SPPIDER-seq: sequence-based partner-aware predictor of protein-protein interaction sites.

Bioinformatics (Oxford, England)·2026
Same author

Design, synthesis, and anti-inflammatory evaluation of novel analogues derived from the natural product reticuline.

Journal of enzyme inhibition and medicinal chemistry·2026
Same author

Late-onset cytomegalovirus pneumonia after autologous stem cell transplantation for angioimmunoblastic T-cell lymphoma: a case report.

Therapeutic advances in infectious disease·2026
Same author

A multifactorial model for chronic obstructive pulmonary disease risk in smokers with positive bronchodilation: a retrospective cohort study.

Therapeutic advances in respiratory disease·2026
Same author

SPPIDER-seq: Sequence-based partner-aware predictor of protein-protein interaction sites.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Apr 25, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

8.3K

Developmental programs of lung epithelial progenitors: a balanced progenitor model.

Jun Yang1, Jichao Chen

  • 1Department of Pulmonary Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Wiley Interdisciplinary Reviews. Developmental Biology
|August 16, 2014
PubMed
Summary

Lung development involves three coordinated programs: branching morphogenesis, airway differentiation, and alveolar differentiation. A balanced progenitor model explains how lung cells form and specialize during development.

More Related Videos

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
11:49

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

8.7K
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

8.8K

Related Experiment Videos

Last Updated: Apr 25, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

8.3K
Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture
11:49

Isolation and Enrichment of Human Lung Epithelial Progenitor Cells for Organoid Culture

Published on: July 21, 2020

8.7K
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

8.8K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Organogenesis

Background:

  • Lung epithelium development transforms progenitors into a complex 3D tubular network.
  • Understanding cell type formation requires knowing both how and where they develop.

Purpose of the Study:

  • To propose a model for lung epithelium development integrating progenitor behavior and differentiation.
  • To explain the spatiotemporal coordination of key developmental programs.

Main Methods:

  • Conceptual model integrating branching morphogenesis, airway, and alveolar differentiation.
  • Balanced progenitor model explaining cell fate decisions.

Main Results:

  • Lung epithelium forms via three coordinated programs: branching morphogenesis, airway, and alveolar differentiation.
  • A balanced progenitor model explains how progenitors switch between developmental pathways based on cues.
  • This model offers insights into preterm lung immaturity and evolutionary aspects.

Conclusions:

  • The balanced progenitor model provides a framework for understanding lung epithelial development.
  • Further research requires advanced gene targeting and 3D imaging for progenitor analysis.