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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Alzheimer's disease: a healthcare burden of epidemic proportion
T S Dharmarajan1, Srinivas G Gunturu2
1Vice-Chairman, Department of Medicine, Clinical Director, Division of Geriatrics, Montefiore Medical Center, North Division, Bronx, and Professor of Medicine and Associate Dean, New York Medical College, Valhalla, NY.
Abstract:
Alzheimer's disease is the most common cause of dementia and increases in prevalence exponentially with age, with trends in the United States likely to worsen in ensuing decades. The pathology in Alzheimer's disease is characterized by an increase in extracellular amyloid plaques and intraneural neurofibrillary tangles, with neuronal destruction in several areas of the brain, and biochemically by a deficiency in acetylcholine; clinical manifestations include progressive loss of memory, change in personality, and behavioral disturbances. Pharmacotherapy includes the T.S. Dharmarajan Srinivas G. Gunturu use of cholinesterase inhibitors and memantine; addressing the many behavioral manifestations of the disease, especially in advanced stages, imposes tremendous burden to caregivers and healthcare resources.
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