Related Experiment Video

Updated: Apr 25, 2026

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

1.7K

Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?

Iciar Martín-Timón1, Cristina Sevillano-Collantes1, Amparo Segura-Galindo1

  • 1Iciar Martín-Timón, Cristina Sevillano-Collantes, Amparo Segura-Galindo, Francisco Javier del Cañizo-Gómez, Section of Endocrinology, Hospital Universitario Infanta Leonor, Facultad de Medicina, Universidad Complutense, Madrid 28031, Spain.

World Journal of Diabetes
|August 16, 2014
PubMed

Insights

Type 2 diabetes significantly increases cardiovascular disease risk due to traditional factors like obesity and hypertension. Non-traditional risk factors also play a crucial role in this heightened cardiovascular morbidity and mortality.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Diseases

Background:

  • Type 2 diabetes mellitus (T2DM) is a chronic condition characterized by insulin deficiency or resistance.
  • Patients with T2DM face a substantially elevated risk of cardiovascular morbidity and mortality compared to non-diabetic individuals.
  • Traditional risk factors like hypertension, dyslipidemia, and obesity are prevalent in T2DM, contributing to cardiovascular disease (CVD).

Purpose of the Study:

  • To review the impact of traditional and non-traditional risk factors on cardiovascular disease in T2DM patients.
  • To elucidate the role of these risk factors in the pathogenesis of excess CVD mortality and morbidity in T2DM.
  • To explore the concept of a shared etiology ('common soil') for T2DM and CVD.

Main Methods:

  • Literature review focusing on traditional and non-traditional risk factors for CVD in T2DM.
  • Analysis of the contribution of these factors to atherosclerosis development and clinical events.
  • Synthesis of evidence regarding the interplay between diabetes and cardiovascular disease pathogenesis.

Main Results:

  • While traditional risk factors explain some of the increased CVD risk in T2DM, they do not account for the entire excess.
  • Non-traditional risk factors are implicated as significant contributors to CVD in T2DM.
  • A complex interplay of both traditional and non-traditional factors drives atherosclerosis progression from endothelial dysfunction to clinical outcomes.

Conclusions:

  • The heightened cardiovascular disease burden in T2DM results from a combination of traditional and non-traditional risk factors.
  • Understanding these factors is crucial for managing CVD risk in patients with type 2 diabetes mellitus.
  • Further research into non-traditional risk factors may reveal new therapeutic targets for preventing CVD in T2DM.

Keywords:
Blood pressureCardiovascular diseaseDyslipidaemiaHomocysteineInflammationInsulin resistanceMicroalbuminuriaObesityPostprandial HyperglycaemiaType 2 diabetes mellitus

More Related Videos

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.2K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.1K

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
8
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.8K
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
12
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.4K
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated...
11