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The Early Determinants of Adult Health Study
E Susser1, S Buka2, C A Schaefer3
1Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, USA ; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA ; New York State Psychiatric Institute, New York, NY, USA ; The Imprints Center for Genetic and Environmental Life Course Studies, Columbia University, Mailman School of Public Health, New York, NY, USA.
Journal of Developmental Origins of Health and Disease
|August 16, 2014
Summary
This study introduces the Early Determinants of Adult Health (EDAH) cohort, examining midlife health differences in siblings based on birth weight for gestational age. Findings explore long-term health outcomes linked to early life development.
Area of Science:
- Epidemiology
- Developmental Origins of Health and Disease (DOHaD)
- Longitudinal Studies
Background:
- Two unique US pregnancy cohorts (1959-1966) were combined to form the Early Determinants of Adult Health (EDAH) study.
- The EDAH study investigates health outcomes in midlife (40s) by comparing same-sex siblings with differing birth weights relative to gestational age.
- Previous research on these cohorts provides context for the EDAH study and related investigations.
Purpose of the Study:
- To introduce the design and rationale of the EDAH study.
- To detail the recruitment and assessment procedures for the core EDAH sample.
- To present the overall design and past work related to the EDAH study.
Main Methods:
- Combining two pregnancy cohorts (1959-1966) to create a sibling sample discordant for birth weight for gestational age.
- Recruitment and assessment of participants for the core EDAH sample.
- Adult follow-up assessments comparing health outcomes in midlife.
Main Results:
- The abstract introduces the EDAH study design and rationale.
- Details are provided on recruitment, assessment methods, and participant characteristics at follow-up.
- Supplementary tables offer further detailed data.
Conclusions:
- The EDAH study provides a unique resource for investigating early determinants of adult health.
- Collaborative follow-up studies extend the core EDAH sample to address specific research questions.
- The endeavor has broader implications for understanding long-term health trajectories.
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