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[Neonatal enterovirus infections reported in France in 2012]

S Soudée1, I Schuffenecker2, J Aberchih1

  • 1Service de réanimation et pédiatrie néonatales, université Paris 7, hôpital Robert-Debré, AP-HP, 48, boulevard Sérurier, 75019 Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|August 16, 2014
PubMed

Insights

Neonatal enterovirus (EV) infections can be severe. Early symptom onset (before 8 days) and specific EV types like CV-B4 increase risk, highlighting the need for prompt diagnosis and monitoring.

Area of Science:

  • Virology
  • Neonatology
  • Infectious Diseases

Context:

  • Enteroviruses (EVs) are common human pathogens, with a significant proportion affecting infants.
  • Neonatal EV infections present a spectrum of illness, from mild symptoms to life-threatening sepsis and multiorgan failure.
  • Understanding risk factors and clinical patterns in neonatal EV infections is crucial for timely intervention.

Purpose:

  • To analyze demographic, clinical, and biological data of neonates hospitalized with EV infections in 2012.
  • To identify subgroups based on symptom onset (before or after 8 days of life) and associated risk factors for severe outcomes.
  • To evaluate the utility of systematic serotyping and liver function monitoring for early risk stratification.

Summary:

  • A study of 120 neonatal EV infections revealed that early symptom onset (before 8 days) was associated with prematurity and low birth weight.
  • Commonly detected EVs included Coxsackievirus B4 (CV-B4) and Enterovirus E-11 (E-11).
  • Severe infections, particularly before 8 days, were linked to significant liver and hematological damage, including thrombocytopenia and coagulopathy.

Impact:

  • This research underscores the importance of systematic EV serotyping in neonates.
  • Biological monitoring of liver function can aid in identifying high-risk infants early.
  • Findings support proactive management strategies to reduce clinical severity and fatality in neonatal EV infections.

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