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Idiopathic Orbital Inflammation Associated With Necrotizing Scleritis and Temporal Bone Inflammation
Sundeep K Kasi1, H Jane Kim, Ryan P Basham
1*Department of Ophthalmology, University of California San Francisco, San Francisco; †California Pacific Medical Center, San Francisco; ‡Department of Ophthalmology, Stanford University School of Medicine, Stanford; §West Coast Retina Medical Group, San Francisco; and ‖Department of Otorhinolaryngology, University of California San Francisco, San Francisco, California, U.S.A.
Abstract:
The authors present a case of aggressive idiopathic orbital inflammation producing necrotizing scleritis along with synchronous tumefactive fibroinflammatory lesion of the temporal bone. A young woman with no medical history presented with sectoral scleritis and mildly reduced vision. Response to initial treatment, which included topical and systemic corticosteroids, as well as systemic nonsteroidal anti-inflammatory drugs, was limited. Over the following months, signs of orbital inflammation developed, including ptosis, proptosis, and limited extraocular motility. MRI revealed both orbital and ipsilateral temporal bone masses. An orbital biopsy was performed revealing a mixed inflammatory infiltrate, whereas a biopsy of the temporal bone mass revealed a tumefactive fibroinflammatory lesion. Biopsy showed no histopathologic evidence of infection nor neoplasm. The patient eventually responded to treatment with systemic prednisone, azathioprine, and rituximab.
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