Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

2.9K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
2.9K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

1.5K
1.5K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
7.1K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

1.5K
1.5K
The Cell Cycle Control System01:28

The Cell Cycle Control System

5.1K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
5.1K
The Cell Cycle Control System02:11

The Cell Cycle Control System

11.8K
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
11.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calculation of state-to-state differential and integral cross sections for atom-diatom reactions with transition-state wave packets.

The Journal of chemical physics·2014
Same author

[Natural attenuation of tetracycline in the water of Taihu Lake under different environmental conditions].

Huan jing ke xue= Huanjing kexue·2014
Same author

The role of AhR in autoimmune regulation and its potential as a therapeutic target against CD4 T cell mediated inflammatory disorder.

International journal of molecular sciences·2014
Same author

Association between polymorphisms in the flanking region of the TAFI gene and atherosclerotic cerebral infarction in a Chinese population.

Lipids in health and disease·2014
Same author

An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer's Disease.

Molecular neurobiology·2014
Same author

Immobilized lipase from Candida sp. 99-125 on hydrophobic silicate: characterization and applications.

Applied biochemistry and biotechnology·2014

Related Experiment Video

Updated: Apr 25, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

18.9K

Hippo pathway key to ploidy checkpoint.

Bin Zhao1, Kun-Liang Guan2

  • 1Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Cell
|August 16, 2014
PubMed
Summary
This summary is machine-generated.

Tetraploid cells, often eliminated by cell cycle arrest or apoptosis, can cause cancer if they survive. Extra centrosomes activate the LATS2 kinase, a key mechanism halting cell division in tetraploid cells.

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

6.5K
Manipulation of Ploidy in Caenorhabditis elegans
07:54

Manipulation of Ploidy in Caenorhabditis elegans

Published on: March 15, 2018

12.1K

Related Experiment Videos

Last Updated: Apr 25, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

18.9K
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

6.5K
Manipulation of Ploidy in Caenorhabditis elegans
07:54

Manipulation of Ploidy in Caenorhabditis elegans

Published on: March 15, 2018

12.1K

Area of Science:

  • Cell biology
  • Cancer research
  • Genomics

Background:

  • Tetraploid cells arise from abnormal cell division.
  • These cells are typically eliminated via cell cycle arrest or apoptosis.
  • Failure to eliminate tetraploid cells contributes to genomic instability and cancer.

Purpose of the Study:

  • To investigate the mechanisms by which tetraploid cells are regulated.
  • To identify key pathways involved in tetraploidy-induced cell-cycle arrest.
  • To understand the role of centrosomes in tetraploidy regulation.

Main Methods:

  • Investigated cell division abnormalities.
  • Analyzed cell cycle progression in tetraploid cells.
  • Examined the activation of the Hippo pathway kinase LATS2.

Main Results:

  • Extra centrosomes were found to activate the Hippo pathway.
  • Activation of LATS2 kinase was identified as a critical event.
  • This activation leads to cell-cycle arrest in tetraploid cells.

Conclusions:

  • Extra centrosomes trigger a defense mechanism against tetraploidy.
  • The Hippo pathway kinase LATS2 plays a crucial role in preventing genomic instability.
  • Understanding this pathway could offer new therapeutic targets for cancer.