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Belizentrin, a highly bioactive macrocycle from the dinoflagellate Prorocentrum belizeanum

Humberto J Domínguez1, José G Napolitano, M Teresa Fernández-Sánchez

  • 1Institute for Bio-Organic Chemistry "Antonio González", Center for Biomedical Research of the Canary Islands, and ∥Department of Chemical Engineering and Pharmaceutical Technology, Faculty of Pharmacy, University of La Laguna , 38206 La Laguna, Tenerife, Spain.

Organic Letters
|August 16, 2014
PubMed

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Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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