Related Experiment Video

Updated: Apr 25, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

15.4K

Disturbed skin barrier in children with chronic kidney disease

Elzbieta Wojtowicz-Prus1, Katarzyna Kilis-Pstrusinska, Adam Reich

  • 1Department of Dermatology, Regional Specialist Hospital, Center for Research and Development, Wroclaw, Poland.

Pediatric Nephrology (Berlin, Germany)
|August 17, 2014
PubMed

Insights

Children with chronic kidney disease (CKD) frequently experience dry skin (xerosis). This skin barrier issue worsens with disease progression, particularly in those on dialysis.

Area of Science:

  • Pediatric Nephrology
  • Dermatology
  • Renal Medicine

Background:

  • Limited data exists on skin manifestations in pediatric end-stage renal failure.
  • Skin barrier dysfunction, specifically xerosis, is a concern in children with chronic kidney disease (CKD).

Purpose of the Study:

  • To evaluate the skin barrier in children across different stages of CKD.
  • To determine the prevalence and severity of xerosis in pediatric CKD patients.
  • To investigate the association between xerosis and demographic factors.

Main Methods:

  • Included 103 children: 72 with CKD (stages 3-5, conservative treatment or dialysis) and 31 controls.
  • Assessed xerosis via self-reporting, clinical evaluation, corneometry, and transepidermal water loss measurements.
  • Correlated skin dryness with age, sex, primary kidney disease, and CKD duration.

Main Results:

  • The majority of pediatric CKD patients reported dry skin.
  • Xerosis was significantly more prevalent in children on dialysis (67.6%) compared to those on conservative treatment (42.1%).
  • No significant differences in age, sex, or CKD duration were found between patients with and without skin dryness.

Conclusions:

  • Impaired skin barrier function is a significant issue in pediatric CKD, worsening as the disease advances.
  • Xerosis is present even in early stages of CKD and requires consideration in patient management.
  • Monitoring and managing skin health is crucial for children with chronic kidney disease.
Abstract

More Related Videos

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium08:46

Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium

Published on: September 1, 2015

9.2K
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

2.9K

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
1.1K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.3K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
676
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
8.1K
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
681
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
524