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Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

Mitochondrial function/dysfunction in white adipose tissue.

Sihem Boudina¹, Timothy E Graham²

¹Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA sihem.boudina@hmbg.utah.edu.

Experimental Physiology

|August 17, 2014

Summary

This summary is machine-generated.

Mitochondria are crucial for white adipocyte function, impacting metabolism and potentially contributing to diseases like diabetes. However, impaired mitochondrial function in these cells doesn't always correlate with systemic insulin sensitivity.

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Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

Area of Science:

Cell Biology
Metabolic Research
Mitochondrial Function

Background:

Mitochondria's role in white adipocytes was historically underestimated due to lower abundance.
Emerging evidence highlights their importance in adipocyte metabolic homeostasis.
Mitochondria are involved in key processes like adipogenesis, fatty acid metabolism, and lipolysis.

Purpose of the Study:

To explore the critical role of mitochondria in white adipocyte function.
To investigate the link between adipocyte mitochondrial dysfunction and metabolic diseases.
To examine the relationship between mitochondrial oxidative capacity and systemic insulin sensitivity in adipocytes.

Main Methods:

Analysis of mitochondrial involvement in adipocyte metabolic pathways.
Examination of studies on altered fat mass (obesity, lipoatrophy) and adipocyte mitochondrial function.
Review of recent research specifically targeting adipocyte mitochondrial function.

Main Results:

Mitochondria are vital for adipogenesis, fatty acid synthesis, branched-chain amino acid catabolism, and lipolysis in white adipocytes.
Impaired mitochondrial function in adipocytes is associated with metabolic disturbances in conditions like obesity.
Studies targeting adipocyte mitochondria show a dissociation between oxidative capacity and systemic insulin sensitivity.

Conclusions:

Mitochondria play a significant, though previously underappreciated, role in white adipocyte function and metabolic health.
Adipocyte mitochondrial dysfunction may contribute to metabolic diseases, but the link to systemic insulin sensitivity is complex.
Further research is needed to fully elucidate the intricate relationship between adipocyte mitochondria and overall metabolic regulation.