Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glutamate Ionotropic Kainate Receptors as Therapeutic Targets in Enzalutamide-Resistant and Neuroendocrine Prostate Cancer.

International journal of molecular sciences·2026
Same author

How does AI perform compared to human expert panels in medical Delphi studies? A pilot study through the lens of pathology.

Journal of pathology informatics·2026
Same author

Finding Holes: Pathologist-Level Performance Using AI for Cribriform Morphology Detection in Prostate Cancer.

European urology open science·2026
Same author

Redefining the Landscape of Genitourinary Cancer Precursors: The International Society of Urological Pathology Consensus Recommendations.

European urology·2026
Same author

AI-discovered cellular morphometric biomarkers in needle biopsy of prostate cancer predict neoadjuvant androgen deprivation therapy response and enable therapeutic targeting of mTOR in androgen deprivation therapy-resistant tumors.

Cancer letters·2026
Same author

Exosomal ZFPL1 Identifies Neuroendocrine and Stem Cell-Like Prostate Cancer Subtypes?

The Prostate·2026

Related Experiment Video

Updated: May 1, 2026

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
05:49

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

8.4K

Prostate pointers and pitfalls: the 10 most prevalent problems in prostate biopsy interpretation.

Kenneth A Iczkowski1

  • 1Medical College of Wisconsin, Milwaukee, WI.

Annals of Diagnostic Pathology
|August 17, 2014
PubMed
Summary

Pathologists face challenges interpreting small prostate cancer samples. This review highlights ten common diagnostic issues in prostate biopsy interpretation, aiding accurate cancer diagnosis.

Keywords:
ASAPHigh-grade prostatic intraepethelial neoplasiaMimicsProstateSubmission

More Related Videos

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.5K
Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

2.5K

Related Experiment Videos

Last Updated: May 1, 2026

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking
05:49

Use of Magnetic Resonance Imaging and Biopsy Data to Guide Sampling Procedures for Prostate Cancer Biobanking

Published on: October 10, 2019

8.4K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.5K
Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
05:35

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

2.5K

Area of Science:

  • Uropathology
  • Surgical Pathology
  • Prostate Cancer Diagnosis

Background:

  • Increasing detection of small prostate cancer volumes presents diagnostic challenges.
  • Pathologists require enhanced skills for accurate interpretation of limited biopsy material.

Purpose of the Study:

  • To review common diagnostic pitfalls in prostate biopsy interpretation.
  • To provide guidance for accurate identification of prostate cancer and its mimics.

Main Methods:

  • Photoessay format reviewing ten common diagnostic problems.
  • Focus on issues encountered in second opinion consultations for prostate biopsies.

Main Results:

  • Suboptimal core submission, small focus atypia, and cytologic ambiguity are frequent issues.
  • Immunostain interpretation, high-grade prostatic intraepithelial neoplasia, and benign mimics pose diagnostic difficulties.
  • Omission of extraprostatic extension/Gleason pattern 5, intraductal carcinoma, and urothelial vs. prostatic origin differentials are critical considerations.

Conclusions:

  • Accurate prostate cancer diagnosis requires careful attention to numerous potential pitfalls.
  • Addressing these diagnostic challenges improves the reliability of prostate biopsy interpretation.