Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stage-Specific Regulation of DNA Damage Repair by the Circadian Regulator, CRY1, in Prostate Cancer.

bioRxiv : the preprint server for biology·2026

Same author

Increased Glucose Availability Sensitizes Pancreatic Cancer to Macrophage-Targeting Immunotherapies.

Cancer research communications·2026

Same author

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

Genes & development·2026

Same author

Urologic Device Innovation and Trends: An Analysis of Food and Drug Administration Approvals From 1990 to 2023.

Urology practice·2026

Same author

Impaired Adipose Anabolism in Pancreatic Cancer Cachexia Is Reversed by HuR Inhibition.

Journal of cachexia, sarcopenia and muscle·2026

Same author

Addressing pancreatic cancer disparities in Oregon's Native American population via tribally responsive research systems with the confederated tribes of warm springs.

Cancer causes & control : CCC·2026

Same journal

Lxrα Deficiency Primes Retinal Degeneration, but Aging Drives Disease Severity.

The American journal of pathology·2026

Same journal

MYC is functionally required in both normal and neoplastic Meibomian glands.

The American journal of pathology·2026

Same journal

Fumaric Acid Esters as Modulators of Ocular Inflammation and Angiogenesis.

The American journal of pathology·2026

Same journal

Krüppel-like factor 5 inhibition rescues cavernous nerve-injured erectile dysfunction by preventing phenotypic switch and mitochondrial dysfunction-dependent apoptosis in corpus cavernosum smooth muscle cells.

The American journal of pathology·2026

Same journal

APOE4 as a Modifier of Chemotherapy Response.

The American journal of pathology·2026

Same journal

Spatial Pathobiology in the Omics Era: Transforming Modern Pathology.

The American journal of pathology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 25, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Fusing transcriptomics to progressive prostate cancer.

Masaya Jimbo¹, Karen E Knudsen², Jonathan R Brody¹

¹Division of Surgical Research, Department of Surgery, The Jefferson Pancreas, Biliary, and Related Cancer Center, Sidney Kimmel Medical College, Philadelphia, Pennsylvania.

The American Journal of Pathology

|August 17, 2014

Summary

This summary is machine-generated.

Researchers identified novel fusion transcripts linked to prostate cancer prognosis. This discovery offers new insights into predicting the disease

More Related Videos

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Related Experiment Videos

Last Updated: Apr 25, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Prostate cancer prognosis remains a critical challenge in clinical oncology.
Identifying reliable biomarkers for predicting disease progression is essential for personalized treatment strategies.

Purpose of the Study:

To highlight the findings of Yu et al. regarding novel fusion transcripts.
To emphasize the strong association of these transcripts with prostate cancer prognosis.

Main Methods:

Review and commentary on the methodologies used by Yu et al.
Analysis of next-generation sequencing data to identify fusion transcripts.

Main Results:

Identification of a set of novel fusion transcripts.
Demonstration of a strong correlation between these transcripts and prostate cancer outcomes.
These findings suggest potential utility as prognostic markers.

Conclusions:

The identified fusion transcripts represent promising biomarkers for prostate cancer prognosis.
Further validation studies are warranted to integrate these findings into clinical practice.