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Predictors of mortality in neonates with meconium aspiration syndrome
Deepak Louis1, Venkataseshan Sundaram, Kanya Mukhopadhyay
1Newborn Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Correspondence to: Dr Venkataseshan Sundaram, Assistant Professor, Newborn Unit, Department of Pediatrics, PGIMER, Chandigarh 160 012, India. venkatpgi@gmail.com.
Objective:
To identify risk factors for mortality in neonates with meconium aspiration syndrome.
Methods:
All neonates (2004-2010) with meconium aspiration syndrome, irrespective of gestation were included. Risk factors were compared between those who died and survived.
Results:
Out of 172 included neonates, 44 (26%) died. Mean (SD) gestation and birth weight were 37.9 (2.3) weeks and 2545 (646g), respectively. Myocardial dysfunction [aOR 28.4; 95% CI (8.0-101); P<0.001] and higher initial oxygen requirement [aOR 1.04; 95% CI (1.02-1.07); P<0.001] increased odds of dying while a higher birth weight [aOR 0.998; 95% CI (0.997-1.00); P=0.005] reduced the odds of dying.
Conclusions:
Meconium aspiration syndrome is associated with significant mortality. Myocardial dysfunction, birth weight, and initial oxygen requirement are independent predictors of mortality.
