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Updated: Apr 25, 2026

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
[Acute stent thrombosis and reverse transient left ventricular dilatation after performing a single-photon emission
B Miranda1, M N Pizzi1, S Aguadé-Bruix2
1Servicio de Cardiología, Hospital Universitari Vall d́Hebron, Barcelona, España.
Insights
A patient developed stent thrombosis after exercise, leading to acute ischemia and reduced ejection fraction. This highlights the risk of thrombosis in recently implanted coronary stents, especially with physical exertion.
Area of Science:
- Cardiology
- Nuclear Medicine
- Cardiovascular Imaging
Background:
- Coronary artery disease management often involves stent implantation.
- Assessing myocardial perfusion is crucial for diagnosing and managing ischemic heart disease.
- Recently implanted stents may be vulnerable to thrombotic events.
Observation:
- A 63-year-old male presented with vegetative symptoms three months post-stent implantation.
- During myocardial perfusion imaging, the patient experienced chest pain and ST elevation.
- Urgent cardiac catheterization revealed stent thrombosis.
Findings:
- Rest gated-SPECT myocardial perfusion imaging demonstrated significant anterior and apical perfusion defects.
- These defects were more severe than those observed during stress imaging.
- Acute ischemia resulted in striking left ventricular dilatation and a reduced ejection fraction.
Implications:
- Intense exercise can transiently activate coagulation and alter hemodynamics.
- This may precipitate thrombosis in non-endothelialized coronary stents.
- The findings underscore the importance of careful patient monitoring after stent placement, particularly concerning physical activity.
Abstract:
A 63-year-old male patient with a history of stent implantation in the left anterior descending three months before. Due to the presentation of vegetative symptoms, he was referred for gated-SPECT myocardial perfusion. During acquisition of the resting images he presented chest pain and ST segment elevation, so that urgent cardiac catheterization was performed, showing stent thrombosis. Rest perfusion imaging showed a defect in anterior and apical perfusion, more severe and extensive than in the stress images, with striking left ventricular dilatation and a fall in the ejection fraction related to the acute ischemia phenomenon. Intense exercise is associated with a transient activation of the coagulation system and hemodynamic changes that might induce thrombosis, especially in recently implanted coronary stents that probably still have not become completely endothelialized.
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