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The mechanism for keratinocyte detaching from pH-responsive chitosan

Yi-Hsin Chen1, Shao-Hsuan Chang2, I-Jong Wang3

  • 1Institute of Polymer Science and Engineering, College of Engineering, National Taiwan University, Taipei, 106, Taiwan.

Biomaterials
|August 18, 2014
PubMed
Summary

Cell detachment from pH-responsive chitosan surfaces was investigated. HaCaT cells showed reduced detachment, linked to calcium-dependent integrin β4 (ITGb4) and laminin interactions, crucial for controlling cell adhesion.

Keywords:
HaCaT cellsIntegrin β4 (ITGb4)LamininpH-responsive chitosan

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