Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Heparin free long-term extracorporeal circulation using bioactive surfaces.

K Mottaghy¹, B Oedekoven, K Pöppel

¹Department of Physiology, Technical University of Aachen, West Germany.

ASAIO Transactions

|July 1, 1989

Summary

Bioactive surfaces enable long-term extracorporeal circulation (ECC) without systemic heparinization. This study demonstrates the feasibility of heparin-free ECC for extended lung support using these advanced materials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to ECMO Assistance during Mechanical Ventilation: Effects Induced on Energetic and Haemodynamic Variables: [Comput Methods Programs Biomed. 2021 Apr; 202:106003. Epub 2021 Feb 14.PMID: 33618144].

Computer methods and programs in biomedicine·2021

Same author

Superimposing hip extension on knee flexion evokes higher activation in biceps femoris than knee flexion alone.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2021

Same author

Longer Achilles tendon moment arm results in better running economy.

Physiology international·2021

Same author

Improved protection of outdoor workers from solar ultraviolet radiation: position statement.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Same author

Dissolved Carbon Dioxide Sensing Platform for Freshwater and Saline Water Applications: Characterization and Validation in Aquaculture Environments.

Sensors (Basel, Switzerland)·2019

Same author

Thoracoabdominal pressure gradient and gastroesophageal reflux: insights from lung transplant candidates.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2018

Area of Science:

Biomedical Engineering
Cardiovascular Surgery
Hematology

Background:

Heparin is traditionally required for extracorporeal circulation (ECC) to prevent clotting.
Bioactive surfaces (HBS) have shown promise in reducing the need for anticoagulation during ECC.

Purpose of the Study:

To investigate the possibility of completely avoiding systemic heparinization during long-term ECC using HBS.

Main Methods:

Seven conscious sheep underwent venovenous bypass with HBS-coated equipment for 24 hours (n=3) or 5 days (n=4).
No heparin was administered throughout the procedures.
Standardized conditions, including blood flow rates and priming volume, were maintained.

Main Results:

Related Experiment Videos

No complications were observed during any experiment.

Coagulation parameters, including partial thromboplastin time and activated clotting time, remained within physiological ranges.

Platelet counts stayed above 80% of baseline, and hemolysis rates were negligible.

Blood gas and vital parameters remained normal throughout the ECC duration.

Conclusions:

Bioactive surfaces (HBS) can be safely used for long-term extracorporeal circulation.
Complete avoidance of systemic heparinization is achievable with HBS in long-term ECC.
This finding has significant implications for reducing bleeding risks associated with anticoagulation in ECC.