Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A novel method for long-term respiratory support.

E Tatsumi1, H Takano, Y Taenaka

  • 1National Cardiovascular Center, Research Institute, Department of Artificial Organs, Osaka, Japan.

ASAIO Transactions
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia.

Rhinology·2024
Same author

Comment on "Ectopic thymic carcinoma of the parotid gland".

International journal of oral and maxillofacial surgery·2024
Same author

Amiodarone-induced pneumonitis.

QJM : monthly journal of the Association of Physicians·2021
Same author

Peracute Bacterial Meningitis due to Infection with Klebsiella pneumoniae in Captive-bred Ruffed Lemurs (Varecia variegate).

Journal of comparative pathology·2017
Same author

Pharmacological Properties of Propiverine Contribute to Improving Lower Urinary Tract Dysfunctions in Rats with Spinal Cord Injuries.

Drug research·2016
Same author

Neural changes in the primate brain correlated with the evolution of complex motor skills.

Scientific reports·2016

Researchers developed a novel extracorporeal membrane oxygenation (ECMO) method using a right ventricular assist device (RVAD) and membrane oxygenator (MO). This innovative approach offers improved long-term respiratory support, potentially serving as a bridge to transplantation.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Respiratory Medicine

Background:

  • Traditional extracorporeal membrane oxygenation (ECMO) faces challenges including bleeding, thrombosis, and blood component damage.
  • Existing methods often struggle with long-term viability and require complex management.

Purpose of the Study:

  • To design and evaluate a novel ECMO system integrating a right ventricular assist device (RVAD) and a membrane oxygenator (MO).
  • To assess the feasibility and efficacy of this new system for prolonged respiratory support in an animal model.

Main Methods:

  • An air-driven diaphragm type RVAD was surgically implanted between the right atrium and pulmonary artery in five goats.
  • A membrane oxygenator (MO), including silicon sheet and novel composite membrane types, was connected to the RVAD outlet conduit.

Related Experiment Videos

  • The system provided respiratory support under systemic heparinization for 4-8 days.

    • Main Results:

    • The novel ECMO system successfully provided respiratory support for 4-8 days without major complications in goats.
    • This method mitigated common ECMO issues such as surgical bleeding, serum leakage, and blood component destruction.
    • The system demonstrated effectiveness in preventing pump-induced blood trauma and fatal systemic thrombosis.

    Conclusions:

    • The developed RVAD-MO system presents a viable alternative for long-term respiratory support.
    • This innovative ECMO approach effectively addresses several limitations of conventional ECMO techniques.
    • The system shows promise as a bridge to lung or heart-lung transplantation.