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Updated: Apr 25, 2026
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Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
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[Crystalluria in ethylene glycol intoxication]
Richard Montagnac1, Maxime Thouvenin2, Grégoire Luxey1
1Service de néphrologie-hémodialyse, hôpital de Troyes, 101, avenue Anatole, 10003 Troyes cedex, France.
Nephrologie & Therapeutique
|August 18, 2014
Summary
Calcium oxalate monohydrate crystals, also known as whewellite, can indicate ethylene glycol intoxication. Their presence may aid diagnosis when the cause is unclear.
Area of Science:
- Toxicology
- Crystallography
- Uropathology
Background:
- Ethylene glycol intoxication is a serious condition that can lead to kidney failure.
- Diagnosis can be challenging, especially when the exposure history is unknown.
Observation:
- The study observed characteristic formations of calcium oxalate monohydrate crystals (whewellite).
- These crystal habits were found to be highly suggestive of ethylene glycol poisoning.
Findings:
- Specific morphological features of whewellite crystals serve as a potential diagnostic marker.
- The presence of these crystals can be a key indicator in diagnosing ethylene glycol intoxication.
Implications:
- This finding can improve the early and accurate diagnosis of ethylene glycol intoxication.
- It offers a valuable diagnostic clue in emergency settings or when definitive exposure history is lacking.
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