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Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
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[Crystalluria in ethylene glycol intoxication].

Richard Montagnac1, Maxime Thouvenin2, Grégoire Luxey1

  • 1Service de néphrologie-hémodialyse, hôpital de Troyes, 101, avenue Anatole, 10003 Troyes cedex, France.

Nephrologie & Therapeutique
|August 18, 2014
PubMed
Summary

Calcium oxalate monohydrate crystals, also known as whewellite, can indicate ethylene glycol intoxication. Their presence may aid diagnosis when the cause is unclear.

Keywords:
Calcium oxalate monohydrate crystalCristallurieCrystalluriaEthylene glycolIntoxicationOxalate de calcium monohydratéWhewelliteÉthylène glycol

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Area of Science:

  • Toxicology
  • Crystallography
  • Uropathology

Background:

  • Ethylene glycol intoxication is a serious condition that can lead to kidney failure.
  • Diagnosis can be challenging, especially when the exposure history is unknown.

Observation:

  • The study observed characteristic formations of calcium oxalate monohydrate crystals (whewellite).
  • These crystal habits were found to be highly suggestive of ethylene glycol poisoning.

Findings:

  • Specific morphological features of whewellite crystals serve as a potential diagnostic marker.
  • The presence of these crystals can be a key indicator in diagnosing ethylene glycol intoxication.

Implications:

  • This finding can improve the early and accurate diagnosis of ethylene glycol intoxication.
  • It offers a valuable diagnostic clue in emergency settings or when definitive exposure history is lacking.