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Marked elevation of serum hyaluronan levels in collagenofibrotic glomerulopathy

Shunsuke Goto1, Kentaro Nakai, Jun Ito

  • 1Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|August 19, 2014
PubMed

Insights

Collagenofibrotic glomerulopathy shows extremely high serum hyaluronan levels. Kidney transplantation may normalize these levels, suggesting hyaluronan as a diagnostic marker for this rare kidney disease.

Area of Science:

  • Nephrology
  • Biochemistry

Background:

  • Collagenofibrotic glomerulopathy is a rare kidney disease.
  • It involves significant type III collagen deposition in glomerular structures.

Observation:

  • Patients with this condition exhibited dramatically elevated serum hyaluronan levels.
  • Hyaluronan levels were over 1,000 times the normal limit in some cases.

Findings:

  • Serum hyaluronidase levels and activity remained normal.
  • Hyaluronan deposition was not prominent in the glomeruli.
  • One kidney transplant recipient showed normalized serum hyaluronan.

Implications:

  • Elevated serum hyaluronan may serve as a specific biomarker for collagenofibrotic glomerulopathy.
  • Kidney transplantation appears to resolve the marked increase in serum hyaluronan.

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