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Updated: Apr 25, 2026
Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
Published on: October 13, 2017
Serum Cytokine Levels in Behçet's Disease
Zeynep Meltem Akkurt1, Mehtap Bozkurt2, Derya Uçmak1
1Department of Dermatology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.
Background:
The aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behçet's Disease and healthy controls.
Methods:
Thirty-five patients with Behçet's disease and 29 age and sex-matched healthy controls were included in the study. The patients were separated into groups with active and inactive disease. Serum IL-2, IL-6, IL-8, IL-10, IL-17A, and IFN-γ levels were determined using the enzyme-linked immunosorbent assay method. Cytokine levels of the two patient groups and healthy controls were compared using SPSS 15.0.
Results:
Ten patients with active disease and 25 patients with inactive disease were present. Serum IL-8 levels of active BD patients were higher compared to inactive patients (P = 0.048) and healthy controls (P = 0.02). IL-8 levels were correlated with the duration of symptoms (r = 0.490, P = 0.003) and time passed since diagnosis (r = 0.579, P ˂ 0.001).
Conclusion:
Behçet's disease involves complex interactions of cells of the immune system, mainly T lymphocytes and neutrophils. Further studies on the cytokine profile in Behçet's disease will aid in elucidation of its pathogenesis.
