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Updated: Apr 25, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

793

Early histopathological changes in new-onset diabetes after kidney transplantation

B Borda1, Y Munir Ibrahim1, C Lengyel2

  • 1Department of Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary.

Transplantation Proceedings
|August 19, 2014
PubMed
Abstract

Insights

New-onset diabetes after transplantation (NODAT) is common after kidney transplants. Tacrolimus-based immunosuppression increased NODAT risk compared to cyclosporine A, with early pathological changes in the renal allograft observed.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Endocrinology

Background:

  • New-onset diabetes after transplantation (NODAT) is a frequent complication following kidney transplant procedures.
  • Understanding the risk factors and early indicators of NODAT is crucial for patient outcomes.

Purpose of the Study:

  • To compare the incidence of NODAT between cyclosporine A-based and tacrolimus-based immunosuppression regimens.
  • To identify early pathological changes in renal allografts associated with NODAT.

Main Methods:

  • Randomized assignment of patients to cyclosporine A or tacrolimus immunosuppression.
  • Performance of fasting and oral glucose tolerance tests to diagnose diabetes status.
  • Analysis of renal allograft biopsies using Banff scoring for rejection and fibrosis.

Main Results:

  • NODAT incidence was significantly higher with tacrolimus (26%) compared to cyclosporine A (14%).
  • Elevated uric acid levels and recipient age were associated with NODAT development.
  • Renal allografts in the NODAT group showed increased acute cellular rejection and interstitial fibrosis/tubular atrophy.

Conclusions:

  • Pathological changes in renal allografts can precede functional impairment in NODAT.
  • Immunosuppression choice significantly impacts NODAT risk.
  • Early detection of allograft pathology may aid in managing NODAT.

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